4-Dioxaspiro[4.5]decan-8-ol

4-Dioxaspiro[4.5]decan-8-ol - Names and Identifiers

Name	1,4-Dioxaspiro(4.5)decan-8-ol
Synonyms	4-Dioxaspiro[4.5]decan-8-ol 1,4-Dioxaspiro(4.5)decan-8-ol 1,4-DIOXA-SPIRO[4.5]DECAN-8-OL 4,4-Ethylenedioxycyclohexanol. 4,4-(Ethylenebisoxy)cyclohexanol 4-Hydroxycyclohexanone ethylene acetal 4-HYDROXYCYCLOHEXANONE MONOETHYLENE KETAL
CAS	22428-87-1
InChI	InChI=1/C8H14O3/c9-7-1-3-8(4-2-7)10-5-6-11-8/h7,9H,1-6H2

4-Dioxaspiro[4.5]decan-8-ol - Physico-chemical Properties

Molecular Formula	C8H14O3
Molar Mass	158.2
Density	1.17±0.1 g/cm3(Predicted)
Boling Point	103-104 °C(Press: 0.55 Torr)
Flash Point	116.5°C
Vapor Presure	0.000993mmHg at 25°C
Appearance	Viscous Liquid
Color	Clear colorless
pKa	15.11±0.20(Predicted)
Storage Condition	Inert atmosphere,2-8°C
Refractive Index	1.485-1.487
MDL	MFCD00067003

4-Dioxaspiro[4.5]decan-8-ol - Risk and Safety

Hazard Symbols	Xi - Irritant
Safety Description	24/25 - Avoid contact with skin and eyes.
HS Code	29339900
Hazard Class	IRRITANT

4-Dioxaspiro[4.5]decan-8-ol - Reference Information

introduction

4-hydroxycyclohexanone ethylene glycol acetal is also called 1, 4-dioxa spiro [4.5] decan-8-ol, which can be used as an intermediate in organic synthesis. It can be obtained by the reduction of 4-dioxa [4,5] decan-8-one.

prepare

250ml three-mouth bottle with thermometer plus 1,4-dioxacyclo [4.5] decane -8-one (10g,64.03mmol,1eq.), MeOH(80ml), stir, a small amount of insoluble, add sodium borohydride (0.61
g 0.6g,3.2mol) twice in ice water bath, 0.5eq.). After addition, the ice was removed and stirred in water bath. TLC(DCM:MeOH = 100:
1,2, 4-dinitrophenylhydrazine color development) showed complete reaction after 0.5h. Add water (40ml), evaporate methanol under reduced pressure, and extract ethyl acetate (50 50 25 25ml). The organic phases were combined, anhydrous magnesium sulfate was dried, filtered by suction, and the filtrate was evaporated under reduced pressure to obtain 10.02g of colorless liquid with 98.9% yield.

Last Update：2024-04-09 21:01:54